Thymol

Thymol is a very powerful germicide, killing the germs of typhoid fever in thirty minutes.
Small doses of Thymus act as a sedative and contrastimulant, the depressive action being preceded by a period of excitation.
Large doses blunt the sensibility and produce motor incoordination and sleep.
Animals poisoned by Thyme sleep standing and are insensible to the prick of a pin. They have muscular contraction and tremors, vertigo and turning movements.
There is an increase of diarrhea, vomiting appears, prostration is extreme, the skin becomes cold and death sets in with all the symptoms of a depressant position and with complete anesthesia. These final symptoms are due to the Thymic acid, which is a camphor.
The following proving was obtained by five students of the class of 1903 of the N.Y. Hom. College, namely, (1) Cook, (2) Benson, (3) Pettet, (4) Kellogg, (5) Miller. These provings are combined with the symptoms obtained by Dr. Camperdon, of Paris, in 1884.
The students, under my supervision, for the first two weeks took one disk medicated with the Tincture of Thymus every hour. Forthe second week took two disks every hour.
Dr. Camperdon gave four to twelve minims three times a day on an empty stomach. During the course of the proving habitual catarrhal and sanguineous discharge diminished in frequency and intensity, leucorrheas became less profuse, less liquid, and even ceased if to the internal medication were added douches of the Oil of Thymol, 1 to 1000. Hemorrhoidal discharges were lessened. Menstruation which lasted in some women until the eighth ortenth day returned to the normal duration and was less watery. From the fourth to the eighth day there was an increase of the vital forces. The pulse increased in fullness. He felt more cheerful. His morale was elevated. Later he became over-excited, and was in a state of constant mental agitation.
Everything he said or did was all right, what others said or did was all wrong (3), 25-32 days.
Irritability agg. at the least opposition (3), 25-32 days.
Goes into a rage over rifles (3) 25-32 days.
Sense of approaching trembling on awaking in AM and in evening (3), 25-32 days.
On the verge of nervous collapse, nerves felt all run down (3), 25-32 days.
Feels as if run down physically (5)20-30 days.
Slight drowsiness (5) 20-30 days.
After stopping the drug had felt much better (5).
Ringing in the ears was repeatedly noticed, accompanied by a feeling of pressure in the head and severe pounding over the temples.
This was followed by partial deafness and in our case by complete deafness.
There was a sensation of burning in the pharynx and the expectoration became scanty and difficult.
The laryngeal mucous membranes exhibited an exanthemata exactly like that produced by large doses of the essence of Turpentine.
Noticed an increasing tendency to take cold in the throat (3) 1-8 days.
Sensation of a grape pulp in the throat, especially in the AM Amel. after eating (3) 15-32 days.
Sore throat, left side, agg. swallowing empty (4) 8 day.
Sore throat, right side, swallowing (1) 9-20 days.
Soreness in throat on rising amel. after breakfast (5) 19 day.
Sore throat agg. AM; momentarily amel. drinking liquids (1)21 day.
Throat sore (4) 24 day.
Return of sore throat (1) 25-32 days.
Throat dry (5) 19 day.
Throat dry (1)21 day.
I wish to here state that these students were examined by Dr. R. M. Jones for their ears, nose and throat, and by Dr. J. W. Dowling for their lungs and heart before, during and after proving. Before proving the students were normal.
Dr. Jones found the following condition in the throat of all five provers after taking the medicine for ten days.
The entire mucous membrane of the pharynx w a deep dark red; over this surface the capillary blood vessels stood out distended to the point of bursting, and yet with all this apparent congestion the subjective symptoms were comparatively slight. This state of affairs did not extend to the nose or ears.
After the drug was stopped the membranes resumed their normal condition. Appetite was increased, the digestion taking place more rapidly.
There was burning and pressure in the stomach, causing pain and vomiting, the ejecta often being tinged with blood; in spite of this discomfort in the stomach the digestion went on unimpaired 4-8 days.
When the dose of Thymus was increased to limit, 12 minims, t. i. d„ on an empty stomach, the effects on the stomach were again affirmed; the appetite kept good and digestion was easy and perfect, but later on the appetite kept good and digestion was easy and perfect, but later on the appetite vanished and he became nauseated.
Loss of appetite (5) 20-30 days.
Felt sick and nauseated while taking the drug (5).
Rumbling of gas in abdomen (4) 22 day.
Sudden great soreness in left testicle, forcing him to walk slowly and with his legs apart (3) 25 day.
The stools become drier and more copious.
Erections at night of short duration. Later, after 30M., t. i. d„ painful erections at night.
The urine showed repeatedly increase in amount. No albumen and no blood, dark, cloudy and two-colored; originally brown or brownish yellow it turned to a reddish brown, due to a large amount of Indican caused by the Thymol (Heinrich Furth, Bonn. 1891).
The urine, while warm, smells strongly of violets, less strong than that produced by Turpentine, thus showing the elimination of the Thymine by the uropoetic organs.
This odor was repeatedly verified.
Urine seems watery (2) 4 day.
Urine dark in color (4) 21 day.
Urine smells strong (4) 10 to 12 days.
Urine dark colored, less strong in odor (4) 14 days.
If the daily dose is increased to thirty minims the odor of the urine and sweat is not increased.
Urine increased in quantity (5) 14 day.
More frequent desire to urinate (1) 2-32 days.
More frequent desire to urinate (2) 4-30 days.
Slight difficult in urinating (2) 4 day.
More frequent desire to urinate (3) 3-32 days.
More frequent desire to urinate (4)11,15,21 days.
More frequent desire to urinate (5) 5-25 days.
Frequent desire to urinate, with burning and smarting (1) 21-32 days.
Large doses of Thyme caused difficulty in urinating with burning along the urethra.
Needle like pains in the urethra while urinating in the evening before retiring have been most marked and constant during the proving (2) 4-32 days.
Smarting and burning in urethra after urinating (1)5-6.
Pricking in urethra as if the urine was washing down fine needles which seem to stick at the end of the urethra (2) 7 day.
Smarting and burning in urethra urinating (1) 10-20 days.
Fine needle-like pains on urinating at intervals (2) 12-19 days.
These needle-like pains were agg. before retiring at night (2).
Pain in urethra on urinating lasted 1 day (5) 13 day.
Pain in urethra while urinating returned (5) 17 day.
Tingling in urethra while urinating (4) 17 day.
Pain in urethra while urinating lasted 8 days (5) 17-25 days.
Pain after urinating one day and absent the next day, only to return on the third day (1)21 day.
Tingling in urethra while urinating (4) 21 day, 22 day.
Smarting pain while urinating (4) 26 day.
The one noticeable feature of this report is the marked increase in the Uric acid; the total amount of urine passed daily remained about the same. It also accounts for the smarting and tingling while urinating, and for the primary exaltation of the spirits.
The pulse becomes slow but increases in fullness 4-8 days.
If the daily dose increased to 30 minims, t. i. d„ on an empty stomach; apparently a dangerous dose; we find, the pulse is quickened becomes small and febrile the appetite vanishes and nausea supervenes. There is a slight diarrhea. He becomes over excited now and then; later on he gets into a state of constant agitation, has loss of sleep with frequent and painful erections.
Transient pains in right shoulder agg. motion (2) 3 day.
Stiffness or soreness in right shoulder agg. motion (2) 3 day.
Transient pains in I. shoulder agg. motion of arm (1)4 day and 5 day.
Dull aching pains about I. shoulder (4) 7 day.
Dull ache in shoulders in AM (4) 9 day.
Dull ache in r. groin(4) 24 day and 25 day.
Transient stiffness or soreness in I. knee agg. motion (2) 3 day.
Spasmodic twitchings of rectus and vastus externus just above knee 3 to 4 sudden contractions of the muscles, then a relaxation, repeated several times (3) 28 day.
About one hour after taking the drug a feeling of warmth sets in followed by gentle sweating, occasionally limited to the face and breast.
Perspiration is produced without effort and becomes odorous.
The Thymic acid is evaporated by the sudoriferous glands and the pulmonary passages, as proved by the odor of thyme in the sweat and breath; even the night robe is scented with the odor of thyme.
Several persons presented at this time a slight scarlatinous roseola with red papules.
Slight pustular eruption on the cheek (4) 22 day.
Pustules on neck (4) 22 day.
Increase of pustules on face and neck (4) 29 day.
Prover 4 never before had pimples.
In persons who have weak pulmonary mucous membranes there appeared a dry painful cough with a sensation of burning in the pharynx with scanty difficult expectoration.